Engineering Diversity

Pamela Palmer, MD, Ph.D., Has Developed a New Wonder Drug for her Company
Pamela Palmer | October 10, 2019

Pamela P. Palmer, M.D., Ph.D., has been Chief Medical Officer and Co-Founder of AcelRx Pharmaceuticals, Inc. since she co-founded the company in July 2005. Earlier, she was an anesthesiologist at University California San Francisco — UCSF.

She was director of the UCSF Pain Center for Advanced Research and Education — PainCARE — between 2005 and 2009. The American Pain Society named the UCSF Pain Management Center and PainCARE jointly as one of only six centers of excellence nationwide.

Opioid Breathalyzer Test Developed
Cristina Davis | October 4, 2019

In a small pilot study, researchers at the University of California, Davis have developed and successfully tested a device that collects minute droplets in breath that can be analyzed in a laboratory for morphine, hydromorphone (Dilaudid) and other opioids.

“Exhaled breath collection represents a painless, easily available, and non-invasive technique that would enable clinicians to make quick and well-informed decisions,” said lead author Cristina Davis, PhD, chair of the Department of Mechanical and Aerospace Engineering at UC Davis. “There are a few ways we think this could impact society.

Computer models show promise for personalizing chemotherapy
Sylvia Plevritis | October 4, 2019

Computers have revolutionized many fields, so it isn’t surprising that they may be transforming cancer research. Computers are now being used to model the molecular and cellular changes associated with individual tumors, allowing scientists to simulate the tumor’s response to different combinations of chemotherapy drugs.

Modeling big data to improve personalized cancer treatment was the focus of a recent episode of the Sirius radio show “The Future of Everything.” On hand was Sylvia Plevritis, PhD, a professor of biomedical data science and of radiology at Stanford, who discussed her work with Stanford professor and radio show host Russ Altman, MD, PhD.

National Academy of Engineering Announces Winners of 2019 Arthur M. Bueche Award
Rod Pettigrew | October 4, 2019

On Sunday, Oct. 6, during its 2019 annual meeting, the National Academy of Engineering (NAE) will present two awards for extraordinary impact on the engineering profession. The Simon Ramo Founders Award will be presented to Cato Thomas Laurencin for his research contributions and leadership in engineering. The Arthur M. Bueche Award will be given to Roderic Ivan Pettigrew for his contributions to technology research, policy, and national and international cooperation.

Roderic Ivan Pettigrew is CEO of Engineering Health (EnHealth) and executive dean for Engineering Medicine (EnMed) at Texas A&M and Houston Methodist Hospital. He will be presented the Arthur M. Bueche Award “for leadership at the NIH and for academic and industrial convergence research and education, resulting in innovations that have improved global health care.” The award recognizes an engineer who has shown dedication in science and technology as well as active involvement in determining U.S. science and technology policy, and includes a commemorative medal.

National Academy of Engineering Announces Winners of 2019 Simon Ramo Founders Awards
Cato Laurencin | October 4, 2019

On Sunday, Oct. 6, during its 2019 annual meeting, the National Academy of Engineering (NAE) will present two awards for extraordinary impact on the engineering profession. The Simon Ramo Founders Award will be presented to Cato Thomas Laurencin for his research contributions and leadership in engineering. The Arthur M. Bueche Award will be given to Roderic Ivan Pettigrew for his contributions to technology research, policy, and national and international cooperation.

Cato T. Laurencin is known worldwide as a leader in biomaterials, nanotechnology, stem cell science, drug delivery systems, and a field he has pioneered, regenerative engineering. Laurencin is being recognized with the Simon Ramo Founders Award “for fundamental, critical, and groundbreaking scientific advances in the engineering of tissues, guiding technology and science policy, and promoting diversity and excellence in science.” The award acknowledges outstanding professional, educational, and personal achievements to the benefit of society and includes a commemorative medal.

This flat structure morphs into shape of a human face when temperature changes
Jennifer Lewis | September 30, 2019

Researchers at MIT and elsewhere have designed 3-D printed mesh-like structures that morph from flat layers into predetermined shapes, in response to changes in ambient temperature. The new structures can transform into configurations that are more complex than what other shape-shifting materials and structures can achieve.

As a demonstration, the researchers printed a flat mesh that, when exposed to a certain temperature difference, deforms into the shape of a human face. They also designed a mesh embedded with conductive liquid metal, that curves into a dome to form an active antenna, the resonance frequency of which changes as it deforms.

High-speed microscope illuminates biology at the speed of life
Elizabeth Hillman | September 27, 2019

The Columbia team behind the revolutionary 3D SCAPE microscope announces today a new version of this high-speed imaging technology. In collaboration with scientists from around the world, they used SCAPE 2.0 to reveal previously unseen details of living creatures — from neurons firing inside a wriggling worm to the 3D dynamics of the beating heart of a fish embryo, with far superior resolution and at speeds up to 30 times faster than their original demonstration.

These improvements to SCAPE, published today in Nature Methods, promise to impact fields as wide ranging as genetics, cardiology and neuroscience.

Malawi study confirms lasting impact of life-saving technology
Rebecca Richards-Kortum | September 20, 2019

Malawi’s national adoption of affordable, rugged, neonatal CPAP technology as a part of routine hospital care resulted in sustained improvements in the survival of babies with respiratory illness, according to a new study in the journal Pediatrics.

Malawi, in southeast Africa, has the world’s highest preterm birth rate, with almost 1 in 5 babies born premature. A study conducted at 26 Malawi government hospitals found that the national adoption of rugged, low-cost, neonatal “continuous positive airway pressure” (CPAP) devices improved survival rates from 49% to 55% for newborns admitted with breathing problems. For newborns with severe breathing problems, survival improved from 40% to 48%.

On-the-move cancer cells prefer a “comfort cruise,” follow predictable paths of least resistance
Cynthia Reinhart-King | September 13, 2019

According to the researchers, migrating cancer cells decide which path in the body to travel based on how much energy it takes, opting to move through wider, easier to navigate spaces rather than smaller, confined spaces to reduce energy requirements during movement. These findings suggest energy expenditure and metabolism are significant factors within metastatic migration, which lends credence to recent clinical interest in the study of metabolomics and the targeting of cellular metabolism as a way to prevent metastasis.

The discoveries appear in a new paper, “Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making,” published today in the journal Nature Communications.

Led by Cynthia Reinhart-King, Cornelius Vanderbilt Professor of Engineering, the research is the first study to quantify the energetic costs of cancer cells during metastasis – enabling the prediction of specific migration pathways. These new findings build on similar research from the Reinhart-King Lab, published earlier this year, which discovered “drafting” techniques used by cancer cells to conserve energy during migration.

Could an Extracellular Matrix Gel Rebuild MI-Damaged Hearts?
Karen Christman | September 11, 2019

For MI survivors with moderate left ventricular (LV) dysfunction, an injectable biomaterial designed to mimic healthy extracellular matrix (ECM) was found to be safe in a phase I study.

Billed as a potential new approach to heart failure, VentriGel is an ECM hydrogel made from decellularized porcine myocardium and delivered by transendocardial injection using a catheter.

No adverse events definitely related to VentriGel were reported among 15 study subjects with LV dysfunction persisting at 60 days to 3 years post-MI and who had received percutaneous coronary intervention, according to Karen Christman, PhD, of the Sanford Consortium for Regenerative Medicine in La Jolla, California, and colleagues in their study published online in JACC: Basic to Translational Science.

Anaerobically Stored Red Blood Cells May Improve Transfusion Outcomes in Hemorrhagic Shock
Pedro Cabrales | September 3, 2019

Transfusion of red blood cells (RBCs) stored anaerobically – in the absence of oxygen – is a promising technique to improve resuscitation from hemorrhagic shock, according to animal studies reported in SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.

“Resuscitation from hemorrhagic shock via transfusion of anaerobically stored RBCs recovered cardiac function, restored hemodynamic stability, and improved outcomes,” write Pedro Cabrales, PhD, of University of California, San Diego, and colleagues. But more research is needed to determine whether the improved recovery seen with anaerobically stored RBCs in rats will translate into benefits for patients in hemorrhagic shock after trauma.

Most Patients Willing to Share Medical Records for Research Purposes
Lucila Ohno-Machado | August 21, 2019

As medicine becomes both bigger and more personalized, the need for massive databases of patient records, such as the 1 million person All of Us Research Program , become increasingly essential to fueling both new discoveries and translational treatments.

But the looming, lingering question is to what degree are individual patients willing to share medical records and biospecimens with researchers and institutions beyond their personal physician or health care system? And more specifically, how should patients be asked and what information are they most likely to share?

In a novel attempt to answer these questions, researchers at University of California San Diego School of Medicine, with collaborators in California, North Carolina and Texas, asked patients at two academic hospitals to respond to a variety of different approaches seeking to share their medical data with other researchers.

NYU Tandon startup paves the way for pesticide-free cannabis, wine grapes, and other high-value crops
Jin Kim Montclare | August 20, 2019

Brooklyn Bioscience, a startup company commercializing university research to detoxify a common and dangerous class of pesticides, recently received another round of funding – this time in the form of a $250,000 grant from the National Science Foundation.

The New York University School of Engineering team behind Brooklyn Bioscience is engineering proteins to remediate and detoxify organophosphates (OPs), which cannot easily be removed by conventional means.

The two-year grant, part of the NSF’s Partnership for Innovation program, was awarded to the startup whose principals include Jin Kim Montclare, a professor of chemical and biomolecular engineering at the NYU Tandon School of Engineering and doctoral candidate Andrew Olsen.

Making microbes that transform greenhouse gases
Ramon Gonzalez | August 13, 2019

Researchers at the University of South Florida are harnessing the power of human physiology to transform greenhouse gases into usable chemical compounds—a method that could help lessen industrial dependence on petroleum and reduce our carbon footprint.

The new biologically-based technique, published in Nature Chemical Biology, was developed by USF Professor Ramon Gonzalez, Ph.D., and his research team. It utilizes the human enzyme, 2-hydroxyacyl-coenzyme A lyase (HACL), to convert specific one-carbon (C1) materials into more complex compounds commonly used as the building blocks for an endless number of consumer and industrial products.

“In humans, this enzyme degrades branched chain fatty acids,” Gonzalez said. “It basically breaks down long carbon chains into smaller pieces. We needed it to do the opposite. So, we engineered the process to work in reverse—taking single carbon molecules and converting them into larger compounds.

Doctors find new ways to reduce unnecessary breast biopsies
Maryellen Giger | August 6, 2019

One out of eight women will be diagnosed with breast cancer at some point in her lifetime. Early detection is the best tool to increase survival rates. Now researchers are looking at a new way to confirm cancer faster during a mammogram while reducing the need for additional testing.

It’s a terrifying moment for any woman. One doctor says they have found something during her mammogram.

AIMBE Past President, Gilda Barabino Receives AlChE Award For Service To Society
Gilda Barabino | July 15, 2019

Gilda A. Barabino, dean of The City College of New York’s Grove School of Engineering, is the recipient of the 2019 AIChE Award for Service to Society. The award, which will be presented at the annual AIChE meeting in November, recognizes outstanding contributions by a chemical engineer to community service and to the solution of socially oriented problems.

Barabino is being acknowledged for her approach in using engineering principles to solve medical issues that include disease therapies and tackling health disparities, as well as for her public policy leadership to advance the engineering profession. She is also noted for her career-long efforts and transformative impact to broaden participation in the engineering fields and professoriate through advocacy, mentorship and professional development of underrepresented minority students and faculty.

Duke biomedical engineering professor wins social impact award
Nimmi Ramanujam | June 20, 2019

Nimmi Ramanujam, the Robert W. Carr, Jr., Professor of Biomedical Engineering at Duke University, has won the 2019 Social Impact Abie Award.

Given by AnitaB.org, a nonprofit organization dedicated to connecting, inspiring and guiding women in computing and organizations that view technology innovation as a strategic imperative, the award recognizes a woman whose work is making a positive impact on women, technology and society, and who has developed technology that caused social change.

An unnatural way to make natural products
Ramon Gonzalez | June 11, 2019

From medicine to fragrances, nature provides many of the key chemical compounds needed in an endless number of pharmaceuticals and consumer products. Now, a cutting-edge technique engineered by researchers at University of South Florida is changing the way scientists isolate these precious molecules.

“Plant natural products are already widely used across so many industries,” said Ramon Gonzalez, Ph.D., professor in the USF Department of Chemical & Biomedical Engineering and a Florida 21st Century World Class Scholar. “Taxus brevifolia, for example, the Pacific yew plant, contains molecules that are used to produce a chemotherapy drug for several cancer treatments. The problem is that many of these products are expensive and difficult to extract efficiently.”

BU researchers develop new metamaterial that can improve MRI quality and reduce scan time
Xin Zhang | June 10, 2019

Could a small ringlike structure made of plastic and copper amplify the already powerful imaging capabilities of a magnetic resonance imaging (MRI) machine? Xin Zhang, Stephan Anderson, and their team at the Boston University Photonics Center can clearly picture such a feat. With their combined expertise in engineering, materials science, and medical imaging, Zhang and Anderson, along with Guangwu Duan and Xiaoguang Zhao, designed a new magnetic metamaterial, reported in Communications Physics, that can improve MRI quality and cut scan time in half.

AIMBE Fellow inducted into the Women in Technology International Hall of Fame
Natalia Trayanova | June 11, 2019

Natalia Trayanova, a professor in the Department of Biomedical Engineering at Johns Hopkins University, will be inducted into the Women in Technology International Hall of Fame in a ceremony today in San Jose, California.

The WITI Hall of Fame was established in 1996 to recognize, honor, and promote the outstanding contributions women make to the scientific and technological communities that improve society. Each year, five women are selected from around the world to receive this honor, and Trayanova now joins the ranks of other scientists, engineers, and CEOs who have made an impact on society through their exceptional contributions to advancing their fields of inquiry.

Terry Woods Honored with Top Annual Award from Key ASTM International Committee
Terry Woods | May. 29, 2019

ASTM International’s committee on medical and surgical materials and devices (F04) presented its top annual award – the Award of Merit – to Terry O. Woods, Ph.D., solid mechanics laboratory leader, U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, in Silver Spring, Maryland, USA. The prestigious award, which includes the accompanying title of fellow, is ASTM’s highest recognition for individual contributions to developing standards.

New approach shows regeneration of severely damaged lungs
Gordana Vunjak-Novakovic | May. 7, 2019

Lung transplantation, the only lifesaving therapy for an increasing population of patients with end-stage lung disease, is severely limited by the number of available donor organs. Currently, up to 80 percent of donor lungs are rejected for serious but potentially reversible injuries. Since the beginning of transplantation in the 1960s, clinicians and scientists have been trying to address the critical shortage of donor organs.

Paula Hammond elected to the National Academy of Sciences for 2019
Paula Hammond | May. 1, 2019

Three MIT professors — Edward Boyden, Paula Hammond, and Aviv Regev — are among the 100 new members and 25 foreign associates elected to the National Academy of Sciences on April 30. Forty percent of the newly elected members are women, the most ever elected in any one year to date.

Membership to the National Academy of Sciences is considered one of the highest honors that a scientist or engineer can receive. Current membership totals approximately 2,380 members and nearly 485 foreign associates.

American Academy of Arts and Sciences Elects Four Berkeley Lab Scientists
Claire Tomlin | Apr. 19, 2019

Four Lawrence Berkeley National Laboratory (Berkeley Lab) scientists have been elected to the American Academy of Arts and Sciences, a prestigious, 239-year old honorary society that recognizes accomplished scholars, scientists and artists in academia, the humanities, arts, business, and government. A bit like Berkeley Lab itself, the Academy also serves as a nonpartisan research center focused on addressing the nation’s greatest scientific and social problems through cross-disciplinary collaboration of its expert members.

Claire Tomlin, biological faculty engineer, Biological Systems and Engineering Division, and a professor of electrical engineering and computer sciences at UC Berkeley. Her research, which is currently conducted primarily at UC Berkeley, explores hybrid systems: complex systems which have discrete event dynamics as well as continuous time dynamics. Her group studies many topics and problems that can be modeled by hybrid systems as well as more general robotics, such as air traffic control automation, algorithms for decentralized optimization, modeling and analysis of biological cell networks, and unmanned aerial vehicle design and control.

Gordana Vunjak-Novakovic Elected to American Academy of Arts & Sciences
Gordana Vunjak-Novakovic | Apr. 18, 2019

Biomedical engineer Gordana Vunjak-Novakovic, PhD, University Professor, has been elected to the American Academy of Arts & Sciences.

In her laboratory at Columbia University Irving Medical Center, Vunjak-Novakovic creates new ways to engineer human tissues that could repair damaged organs, help scientists study development and disease, and provide faster methods for testing new drugs..

Kristi Anseth elected to American Academy of Arts and Sciences
Kristi Anseth | Apr. 17, 2019

The American Academy of Arts and Sciences announced today that CU Boulder Professor Kristi Anseth has been elected to its 2019 class. Anseth is among more than 200 individuals selected this year for their exceptional achievements in the arts and sciences, business, philanthropy and the public sector.

Founded in 1780, the American Academy of Arts and Sciences is an honorary society that recognizes and convenes leaders from a variety of disciplines to address critical issues facing the nation and the world. The academy’s projects and publications inform public policy for the benefit of all.

Cato Laurencin Elected to American Academy of Arts and Sciences
Cato Laurencin | Apr. 17, 2019

Two UConn professors, Dr. Cato Laurencin and physics professor Nora Berrah, have been elected as members to the historic and prestigious American Academy of Arts and Sciences. This year, more than 200 individuals were elected to the academy with compelling achievements in academia, business, government, and public affairs.

“One of the reasons to honor extraordinary achievement is because the pursuit of excellence is so often accompanied by disappointment and self-doubt,” said David Oxtoby, president of the academy. “We are pleased to recognize the excellence of our new members, celebrate their compelling accomplishments, and invite them to join the Academy and contribute to its work.”

High-speed, 3D microscope captures stunning videos of fruit fly nerve cells in action
Elizabeth Hillman | Mar 7, 2019

Columbia engineers and neuroscientists have joined forces to create 3D videos of individual nerve cells moving, stretching and switching on inside fruit fly larvae as they move. Data gleaned from these videos reveals how nerve cells called proprioceptive neurons work together to help the body sense where it is in space. To accomplish this feat, the researchers harnessed SCAPE, a cutting-edge microscope developed at Columbia that images neurons at lightning-fast speeds.

These findings, published today in Current Biology, illustrate SCAPE’s ability to reveal the inner workings of the nervous system in unprecedented detail. By creating 3D, live action images of nerve cells in larvae as the animals crawled, SCAPE allowed the researchers to see exactly how those cells along the body wall reported movements back to the brain.

New optical imaging system could be deployed to find tiny tumors
Paula Hammond | Mar 7, 2019

Many types of cancer could be more easily treated if they were detected at an earlier stage. MIT researchers have now developed an imaging system, named “DOLPHIN,” which could enable them to find tiny tumors, as small as a couple of hundred cells, deep within the body.

In a new study, the researchers used their imaging system, which relies on near-infrared light, to track a 0.1-millimeter fluorescent probe through the digestive tract of a living mouse. They also showed that they can detect a signal to a tissue depth of 8 centimeters, far deeper than any existing biomedical optical imaging technique.

Tissue model reveals how RNA will act on the liver
Sangeeta Bhatia | Mar 5, 2019

Novel therapies based on a process known as RNA interference (RNAi) hold great promise for treating a variety of diseases by blocking specific genes in a patient’s cells. Many of the earliest RNAi treatments have focused on diseases of the liver, because RNA-carrying particles tend to accumulate in that organ.

MIT researchers have now shown that an engineered model of human liver tissue can be used to investigate the effects of RNAi, helping to speed up the development of such treatments. In a paper appearing in the journal Cell Metabolism on March 5, the researchers showed with the model that they could use RNAi to turn off a gene that causes a rare hereditary disorder. And using RNA molecules that target a different gene expressed by human liver cells, they were able to reduce malaria infections in the model’s cells.

“Antibody-like” T Cell Receptors May Be New Potential Treatment for Cytomegalovirus (#CMV) and Brain Tumors
Jennifer Maynard | Mar 4, 2019

Texas ChE Professor Jennifer Maynard and her research team have engineered “antibody-like” T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40. These receptors represent a new potential treatment option, could aid the development of CMV vaccines and might also be used to target brain tumors.

Dawn Elliott honored by Orthopaedic Research Society
Dawn Elliott | Feb 15, 2019

Some professors shine most brightly in the lab. Others are particularly excellent mentors, inspiring students and other faculty members to reach new heights in their careers. Then, there are those who excel at both.

Dawn Elliott, chair of the Department of Biomedical Engineering at the University of Delaware, is being recognized as one of those multitalented academics. Elliott, a Blue and Gold Professor of Biomedical Engineering, is the inaugural recipient of the Orthopaedic Research Society’s Adele L. Boskey, PhD Award.

Initiative Will Bring Together Engineers at UCSF to Tackle Challenges in Health
Tejal Desai | Feb 15, 2019
Tejal Desai Named Director of UCSF Health Innovation Via Engineering Program

Tejal Desai Named Director of UCSF Health Innovation Via Engineering Program

A new initiative at UC San Francisco will bring together engineers to tackle some of the most urgent challenges in health.

The Health Innovation Via Engineering (HIVE) program will be led by Tejal Desai, PhD, the chair of the Department of Bioengineering and Therapeutic Sciences, a joint department of the UCSF Schools of Pharmacy and Medicine.

A How-To Guide for Promoting Diversity and Inclusion in Biomedical Engineering
Naomi Chesler | Feb 11, 2019

To accelerate the development of an inclusive culture in biomedical engineering (BME), we must accept complexity, seek to understand our own privilege, speak out about diversity, learn the difference between intent and impact, accept our mistakes, and learn how to engage in difficult conversations. In turn, we will be rewarded by the ideas, designs, devices and discoveries of a new generation of problem solvers and thought leaders who bring diverse experiences and perspectives.

Dr. Laurencin receives 2019 AAAS Philip Hauge Abelson Prize
Cato T. Laurencin | Jan. 30, 2019

Dr. Cato T. Laurencin, founding director of the Institute for Regenerative Engineering and the Sackler Center for Biomedical, Biological, Physical and Engineering Sciences at the University of Connecticut, is the winner of the 2019 Philip Hauge Abelson Prize, presented by the American Association for the Advancement of Science.

An eminent biomedical engineer and orthopedic surgeon, Laurencin is being honored for his unique contributions to the advancement of science. The Abelson Prize recognizes his global leadership in biomedical technology innovation, public service in shaping United States technology policy and invaluable mentorship to a generation of minority scientists.

Emery N. Brown Awarded CMU’s Dickson Prize in Science
Emery Brown | Jan. 24, 2019

Carnegie Mellon University will award the Dickson Prize in Science to Dr. Emery N. Brown, an esteemed anesthesiologist, neuroscientist and statistician. He is the Edward Taplin Professor of Medical Engineering and Computational Neuroscience at Massachusetts Institute of Technology , the Warren M. Zapol Professor of Anesthesia at Harvard Medical School and a practicing anesthesiologist at Massachusetts General Hospital.

Identifying Cancer-Driving Gene Mutations – An Interview by Cancer Network
Rachel Karchin | Dec. 20, 2018

Rachel Karchin, PhD, is a professor of biomedical engineering, oncology, and computer science, with joint appointments at the Whiting School of Engineering and School of Medicine at Johns Hopkins University in Baltimore. She is a core member of the Institute for Computational Medicine.

A computational biologist, Dr. Karchin develops algorithms and software to analyze genomic data and interpret its impact on human disease. Her most recent work has focused on cancer and the effects of germline and somatic alterations and their contributions to progression models of tumor evolution. She led the computational efforts to identify driver mutations for the Johns Hopkins Sidney Kimmel Cancer Center’s pioneering cancer sequencing projects, and she co-led The Cancer Genome Atlas (TCGA) PanCancer Atlas Essential Genes and Drivers Analysis Working Group.

Fabrication of Shape-conformable Batteries Based on 3D-printing Technology
Jennifer A. Lewis | Dec. 19, 2018

Flexible, wireless electronic devices are rapidly emerging and have reached the level of commercialization; nevertheless, most of battery shapes are limited to either spherical and/or rectangular structures, which results in inefficient space use. Professor Il-Doo Kim’s team from the Department of Materials Science at KAIST has successfully developed technology to significantly enhance the variability of battery design through collaboration research with Professor Jennifer A. Lewis and her team from the School of Engineering and Applied Sciences at Harvard University.

Most of the battery shapes today are optimized for coin cell and/or pouch cells. Since the battery as an energy storage device occupies most of the space in microelectronic devices with different designs, new technology to freely change the shape of the battery is required.

FDA approves device based on Vanderbilt invention to ID parathyroid during head and neck surgeries
Anita Mahadevan-Jansen | Dec. 17, 2018

Ten years after Professor of Biomedical Engineering Anita Mahadevan-Jansen discovered that parathyroid tissues glow under near-infrared light, the FDA has approved a device based on the technology for surgical use.

She and her team developed the technology at the Vanderbilt Biophotonics Center. The device called “PTeye” has been tested at Vanderbilt University Medical Center and Ohio State University Medical Center in an 81-patient clinical study, leading to regulatory approval. It enables real-time identification of parathyroid tissue during thyroid and parathyroid surgeries.

Researchers evaluate pMSCs sheets for engineered repair and regeneration of heart tissue
Joyce Wong | Dec. 7, 2018

The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. Congenital heart disease is the leading cause of birth-defect-related illness and death. The placenta can be readily collected at birth and the cells harvested for pediatric reparative procedures, as described in the study published in Tissue Engineering, Part A, peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Tissue Engineering website through January 7, 2019.

Sitaram Emani, MD, Breanna Piekarski, RN, and Sirisha Emani, Children’s Hospital, Boston, MA and Erin Roberts, Kevin Huang, and Joyce Wong, PhD, Boston University, MA are the coauthors of the article entitled “Evaluation of Placental Mesenchymal Stem Cell Sheets for Myocardial Repair and Regeneration .” In the study, the researchers evaluated MSCs independent of their source, demonstrated their ability to form cell sheets, and described other beneficial effects related to paracrine section and cell-cell interactions at the site of MSC implantation. The ability of MSCs to secrete factors to induce cardioprotection, stimulate angiogenesis, and promote migration, proliferation and differentiation of local cardiac stem cells can all affect tissue repair.

JenaValve Technology Receives FDA Approval for Expanded IDE Enrollment in the Treatment of Patients with Severe Aortic Stenosis and Severe Aortic Regurgitation
Victoria Carr-Brendel | Dec. 3, 2018

JenaValve Technology, Inc., a developer and manufacturer of differentiated transcatheter aortic valve replacement (TAVR) systems, today announced U.S. Food and Drug Administration (FDA) approval of expansion of its Investigational Device Exemption (IDE) feasibility studies for the JenaValve Pericardial TAVR System with the Everdur™ transcatheter heart valve (THV) and Coronatix TM Transfemoral Delivery Catheter. The approval expands eligible patient enrollment from 20 patients at extreme or high surgical risk (10 aortic stenosis [AS], 10 aortic regurgitation [AR]) to 80 patients at extreme or high surgical risk (40 AS, 40 AR) at up to 10 U.S. sites.

The prospective IDE studies are part of a larger, ongoing CE Mark clinical program investigating the JenaValve Pericardial TAVR System for the same indications at centers of excellence in Europe and New Zealand.

With these nanoparticles, a simple urine test could diagnose bacterial pneumonia
Sangeeta Bhatia | Nov. 29, 2018

Pneumonia, a respiratory disease that kills about 50,000 people in the United States every year, can be caused by many different microbes, including bacteria and viruses. Rapid detection of pneumonia is critical for effective treatment, especially in hospital-acquired cases which are often more severe. However, current diagnostic approaches often take several days to return definitive results, making it harder for doctors to prescribe the right treatment.

MIT researchers have now developed a nanoparticle-based technology that could be used to improve the speed of diagnosis. This type of sensor could also be used to monitor whether antibiotic therapy has successfully treated the infection, says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science and the senior author of the study.

Potential arthritis treatment prevents cartilage breakdown
Paula Hammond | Nov. 28, 2018

Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. Some drug treatments can help alleviate the pain, but there are no treatments that can reverse or slow the cartilage breakdown associated with the disease.

In an advance that could improve the treatment options available for osteoarthritis, MIT engineers have designed a new material that can administer drugs directly to the cartilage. The material can penetrate deep into the cartilage, delivering drugs that could potentially heal damaged tissue.

Guiseppi-Elie named associate dean of EnMed
Anthony Guiseppi-Elie | Nov. 27, 2018

Dr. Anthony Guiseppi-Elie has been named associate dean of Engineering Medicine (EnMed) at Texas A&M University. He is currently a TEES Research Professor and professor in the Department of Biomedical Engineering with a courtesy appointment in the Department of Electrical and Computer Engineering.

EnMed is Texas A&M University’s innovative engineering medicine school option at Houston Methodist Hospital, developed to educate a new kind of physician to create transformational technology for health care.

Quantitative Analysis Improves Breast Screening: Research Highlights from RSNA
Elizabeth Burnside | Nov. 27, 2018

Quantitative analysis improves breast cancer screening, according to four abstracts at the 104th Annual Radiological Society of North America (RSNA) meeting, November 25–30, 2018. The investigators all used Volpara Solutions’ breast imaging analysis tools, including assessment of volumetric density and compression pressure, in their research.

In the study “Using Quantitative Breast Density Analysis to Predict Interval Cancers and Node Positive Cancers in Pursuit of Improved Screening Protocols,” (SSE01-03, Monday, November 26, 3:20–3:30 PM, Room: E451B), Elizabeth Burnside, MD, and colleagues investigated whether quantitative breast density can predict interval cancers and node-positive, screen-detected cancers in order to serve as a biomarker to consider more aggressive screening to improve early detection. The study involved 599 cases of screen-detected cancers and interval cancers and 605 controls from the UK NHS Breast Screening Programme. For each case, breast density was assessed by a radiologist using a visual analog scale (VAS) and BI-RADS 5th Edition density categories and using fully automated Volpara®Density™ software to calculate fibroglandular volume (FGV) and Volpara Density Grade (VDG®).

Martine LaBerge honored as Fellow by the Biomedical Engineering Society
Martine LaBerge | Nov. 1, 2018

Martine LaBerge of Clemson University is one of the newest Fellows in the Biomedical Engineering Society, an honor recognizing her for exceptional achievements and experience in biomedical engineering.

LaBerge is chair of the Department of Bioengineering at Clemson and executive director of the Clemson University Biomedical Engineering Innovation Campus, or CUBEInC, in Greenville.

Guillermo Ameer Receives Key to Panama City
Guillermo Ameer | Oct. 31, 2018

Northwestern Engineering’s Guillermo Ameer, a pioneer in the field of regenerative engineering, was presented the Key to Panama City, Panama, by Vice Mayor Raisa Banfield last week. The event was covered by Telemetro, a national Spanish-language television network based in Panama City.

Ameer, the Daniel Hale Williams Professor of Biomedical Engineering with the McCormick School of Engineering, was in his hometown to attend at APANAC 2018, the XVIII Congreso Nacional de Ciencia y Tecnologia, the nation’s premier science conference. He also serves as a professor of surgery at Northwestern University’s Feinberg School of Medicine, and he is the director of the Center for Advanced Regenerative Engineering (CARE).

Reinhart-King receives the inaugural BMES Mid-Career Award
Cynthia Reinhart-King | Oct. 25, 2018

Cynthia A. Reinhart-King, a nationally recognized cellular bioengineer, is the inaugural recipient of the Biomedical Engineering Society’s Mid-Career Award. Reinhart-King delivered the award lecture Saturday, Oct. 20, at the BMES 2018 Annual Meeting in Atlanta.

Reinhart-King received the 2010 Rita Schaffer Young Investigator Award and she is the only person to have received two of three major awards from the BMES.

Cryptographic protocol enables greater collaboration in drug discovery
Bonnie Berger | Oct. 18, 2018

MIT researchers have developed a cryptographic system that could help neural networks identify promising drug candidates in massive pharmacological datasets, while keeping the data private. Secure computation done at such a massive scale could enable broad pooling of sensitive pharmacological data for predictive drug discovery.

Datasets of drug-target interactions (DTI), which show whether candidate compounds act on target proteins, are critical in helping researchers develop new medications. Models can be trained to crunch datasets of known DTIs and then, using that information, find novel drug candidates.